Shops in the city centre pulled down their shutters and currency traders fled their pavement stalls as dozens of anti-riot police patrolled the streets.
Demonstrators led by the anti-government pressure group Tajamuka (We Are Agitated) demanded the resignation of central bank chief John Mangudya over severe cash shortages.
The police spokesperson declined comment on the demonstration.
Zimbabwe in 2009 abandoned its own currency in favour of the US dollar due to hyperinflation.
Last year it introduced “bond notes”, a parallel currency pegged to the US dollar, but recent price rises in basic goods such as cooking oil and sugar have revived fears of another inflation boom.
In 2016, a series of large street protests against the economic crisis under Mugabe were halted by a security crackdown.